Hepatitis D, also referred as Hepatitis D virus (HDV) and classified as Hepatitis delta virus, is a disease caused by a small circular enveloped RNA virus. HDV is considered to be a subviral satellite because it can propagate only in the presence of the hepatitis B virus (HBV). Transmission of HDV can occur either via simultaneous infection with HBV (coinfection) or superimposed on chronic hepatitis B or hepatitis B carrier state (superinfection).
Both superinfection and coinfection with HDV results in more severe complications compared to infection with HBV alone. These complications include a greater likelihood of experiencing liver failure in acute infections and a rapid progression to liver cirrhosis, with an increased chance of developing liver cancer in chronic infections. In combination with HBV, HDV has the highest mortality rate of all the hepatitis infections of 20%.
HDV PCR kits are an in vitro nucleic acid amplification test for qualitative and quantitative detection of hepatitis virus D RNA in the clinical materials (blood plasma). Kits contain Internal Control in order to check the isolation and Reverse transcription proces and to identify possible reaction inhibition.