Anti-Borrelia IgG specifically detects IgG class antibodies against VlsE (VMP-like sequence expression site), DbpA (decorin-binding-protein A), OspC (outer-surface-protein C) und p83/p100 (chromosomally encoded high molecular weight protein) of the three major human pathogenic Borrelia species, B. burgdorferi sensu stricto, B. afzelii and B. garinii. These tailor-made antigen profiles cover the relevant epitopes for specific antibody recognition, avoiding cross-reactivity with other pathogenic or common commensal bacteria.
Borrelia burgdorferi belongs to the family of spirochetes. Transmission to humans is caused by ticks. In most cases Erythema migrans is the first clinical sign of infection. Spreading of the pathogen may be followed by complications in later stages of the disease, especially neuroborreliosis and Lyme arthritis. In untreated patients the disease may take a severe course leading to persistent chronic infection.
Progression of Lyme disease can be prevented by administration of antibiotics. A careful diagnosis is therefore critical for further treatment of the patient. Determination of IgG and IgM antibodies also plays a crucial role in Borrelia diagnostics. In later stages detection of Borrelia-specific antibodies is essential to confirm clinical suspicion of Lyme disease. Detection of intrathecal antibody production is conclusive for the diagnosis of chronic neuroborreliosis. In Lyme arthritis extremely high titres of IgG antibodies are found, with IgM antibodies being completely absent.