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Main pageHealth A-ZSymptomsGeneral → Lactoacidotic coma
16.04.2014
Lactoacidotic coma

 

 

Definition

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Definition

Lactoacidotic coma 

- can be a consequence of high doses of biguanide peroral antidiabetics - their induction of anaerobic glycolysis

- contributes peripheral hypoperfusion (diabetic micro/macro-angiopathies) increasing anaerobic metabolism

- low ability to compensate via hyperventilation in old people as well as through decreased kidney function

- lactic acid over 8 mmol/l (can be decreased by hemodialysis)

- mechanism of coma development as in ketoacidosis - via increased vessel permeability and brain edema formation

 

 

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