In pregnancy, kidney disease has long been associated with adverse outcomes for both mother and fetus. With respect to the fetus, adverse outcomes include problems such as fetal prematurity, low birth weight, and neonatal death, For the mother, adverse outcomes include preeclampsia, eclampsia, or abruptio placenta (premature placenta separation with hemorrhage). Consistent with the above, IgAN introduces a number of complications when either being pregnant, or contemplating pregnancy. IgAN pregnancies should always be considered higher risk, but they are not impossible. Each case is different, and any woman considering pregnancy would be well-advised to consult her nephrologist or other attending physician before contemplating pregnancy.
Many women with IgAN have conceived successfully, however, your nephrologist's recommendation or advice will depend on your individual circumstances. Factors that may be considered are degree of existing renal failure (that is, what your kidney function is, and if it's less than about 70%), the amount of proteinuria you have, whether you have high blood pressure or not, and also some of your biopsy findings (any sign of significant tubulointerstitial involvement). You might be asked to wait until your IgAN is stable, if for example, you are dealing with nephrotic syndrome, or if you are having frequent "flare-ups" involving blood in the urine.